Big Compute

Celebrating innovation in a world of virtually unlimited compute power, one story at a time.

Latest Episodes

20

November 15, 2022 01:10:06
The Computational Science of Drug Development

The Computational Science of Drug Development

At the beginning of 2020, while a pandemic of epic proportions shut down most of the world, the life sciences industry was kicked into high gear, pushing to do what had never been done before – create a vaccine in less than four years.  Thankfully, modern day computational science lended a hand, making the previously impossible, possible.  In this episode, we speak to someone on the front lines of vaccine and drug development – Steve Mehrman of Johnson & Johnson, who harnesses computational power on a daily basis to elevate one of the most important aspects of our lives – human health. ...

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19

April 12, 2022 00:58:13
A Cloud Startup Story (Part 2)

A Cloud Startup Story (Part 2)

More than a decade ago, a young Joris Poort stepped into a small Silicon Valley apartment for the first time, ready to make an impact on the world.  What would follow was months of rejection from investors to his big idea of how to accelerate innovation in an up-and-coming new normal of cloud high performance computing.  In this second part of a 2-part series about how Rescale began, we hear how Joris persevered through challenges, was accepted into Y Combinator, and how he landed his first check, ultimately launching the business – and vision – he had for the world. ...

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18

March 29, 2022 00:58:36
A Cloud Startup Story (Part 1)

A Cloud Startup Story (Part 1)

Amazon started as a bookseller.  BloomNation was founded with money won in a Poker tournament.  The creator of Paul Mitchell hair products was homeless before starting the company with a friend for $700.  Each product or service we use on a daily basis has a unique startup story behind it.  In this episode, we hear from Joris Poort, founder and CEO of cloud high performance computing company, Rescale, about what led him to quit his job at Boeing to start a tech company.  From his birth in the Netherlands to finding himself surrounded by consultants at Harvard Business School – Joris’s story is proof that it takes a special kind of person with a special kind of vision to create a business that pushes innovation to the next level. ...

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17

December 21, 2021 00:55:10
How to Tell Your Family About HPC

How to Tell Your Family About HPC

For those working with high performance computing in any capacity, sometimes talking about it with your family can be a little… confusing.  And with the holiday season upon us, many of us will undoubtedly be asked by well-meaning family members, “What’s going on with work?”  So today, we figured – Rather than bore the non-technical with technical jargon, why not just talk about some of the awesome ways high performance computing is changing the world?  In this episode, we revisit the 2020 Big Compute conference talk by Barry Bolding of AWS about just that – how HPC makes our lives better.  So when you’re sipping eggnog with the family and the question of work comes up, you can brighten their eyes instead of put them to sleep. ...

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16

November 30, 2021 01:07:42
Protecting Football Players’ Brains

Protecting Football Players’ Brains

It hasn’t even been two decades since the discovery was made -- Small repetitive hits to the head over time accumulated in football games and practices can build up into something significant and scary:  chronic traumatic encephalopathy, or CTE.  But with no sign that American football is going away anytime soon, the question remains of what can be done to better protect players against life-altering injuries like this?  In today’s episode, Jolie and Ernest speak to Tate Fonville of Liberty University about a new approach to designing a football helmet that is more likely to protect against damage to the brain -- by using computational simulation. ...

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17

November 16, 2021 00:46:34
At the Heart of Simulation (Part 2)

At the Heart of Simulation (Part 2)

In the last episode, we were introduced to Tom -- a man who was flung into a medical twilight zone of heart issues and the procedures to fix them.  In this continuation of the story, meet Steve Kreuzer -- an engineer from Exponent who specializes in assisting in the development of the very kind of technology that saved Tom’s life.  Steve walks us through just what kind of technology it takes to create these life-saving devices, and how much more complex it is when you’re trying to predict how these devices will interact with human tissue.  ...

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